Southwest Illinois Vacations from $353
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Your Southwest Illinois Vacation
When it's time for your next epic adventure, our Southwest Illinois vacation packages are the answer. Culture and history are among the many things that make this destination such a special place. Begin your trip to Southwest Illinois with some time exploring O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Marion is another city that lures travelers from all over. Lake of Egypt and Crab Orchard National Wildlife Refuge are two of the top places to see in this destination. From the moment you book your Southwest Illinois vacation to the second you come back home, Expedia will be with you each step of the way.
The Latest Southwest Illinois vacation packages
Hilton Garden Inn Chesterfield
Reviewed on Dec 22, 2025
DoubleTree by Hilton Hotel St. Louis - Chesterfield
Reviewed on Nov 26, 2025
Where to stay in Southwest Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Discover the most popular places to visit in Southwest Illinois
Southern Illinois University
Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.
Giant City State Park
Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.
Ferne Clyffe State Park
You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.
Southwest Illinois Hotel Deals
Drury Plaza Hotel Mt. Vernon
Clean rooms, good breakfast
Reviewed on Dec 24, 2025
Super 8 by Wyndham O'Fallon
Quick and easy check in
Reviewed on Dec 24, 2025
Drury Inn & Suites St. Louis Fairview Heights
Wonderful stay! Staff was kind, efficient, and informative. Having drinks, appetizers, and a full breakfast was a definite plus. The best night of rest in 2 weeks away from home, the bed was not a board! Definitely choosing Drury again over others!
Reviewed on Dec 23, 2025
Find the Best Southwest Illinois Vacation Packages
Southwest Illinois Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
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